The section of wood, from the original tree from which the apple fell that inspired Newton’s theory of gravity, is normally held in the Royal Society’s archives.
It was lent to British-born astronaut Dr Piers Sellers, who will be taking it into orbit, as part of the academic institution’s 350th anniversary celebrations.
The tree sample will be accompanied on its trip into space by an image of Sir Isaac, also donated by the Royal Society.
Dr Sellers said: ”We’re delighted to take this piece of Sir Isaac Newton’s apple tree to orbit. While it’s up there, it will be experiencing no gravity, so if it had an apple on it, the apple wouldn’t fall.
”I’m pretty sure that Sir Isaac would have loved to see this, assuming he wasn’t spacesick, as it would have proved his first law of motion to be correct. After the flight, we will be returning the piece of tree and a flown picture of Sir Isaac Newton back to The Royal Society.”