Ötzi the Iceman’s genome sequenced

Published on March 1st, 2012 | by Admin

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iceman

Ötzi the Iceman, whose 5,300-year-old body was found preserved in the Alps, has had his genome sequenced, revealing some new insights into his health.

In 2008, scientists reported the complete sequence of DNA taken from Ötzi’s cellular mitochondria. It contained mutations not found in present-day populations, and led to speculation that the iceman had belonged to a people that has vanished from Europe. To get a better picture of Ötzi’s ancestry and a look at some of his genetic traits, Zink’s team sequenced the DNA from the nuclei of cells taken from a sliver of the iceman’s pelvic bone. The sequence accounts for around 96% of Ötzi’s genome.

The data suggest that Ötzi had brown eyes and type-O blood, and was lactose intolerant. Zink’s team also discovered gene variants linked to hardened arteries, which could help to account for calcium deposits found in scans3. “He wasn’t obese, he was very active, he doesn’t have strong risk factors for developing calcification of his heart,” says Zink. “Perhaps he developed this due to a genetic predisposition.”

[Full story]

Story: Ewen Callaway, Nature | Photo: S. Marco/Eurac

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